A Stability Indicating Method was Developed and Validation for the Estimation of Carbamazepine in Bulk and Tablet Dosage form by UV-Spectroscopic Techniques

Carbamazepine is an anticonvulsant. It works by decreasing nerve impulses that cause seizures and pain, such as trigeminal neuralgia diabetic neuropathy. well known contemporary pharmaceutical analysis establishes robust, sensitive, economic, stability-indicating analytical procedures. The current study aimed to develop assess UV-spectrophotometric (zero order, first second area under the curve) methods for estimating carbamazepine in its dosage form. Method A a simple zero-order spectrophotometric method determining at 285 nm, correlation coefficient linearity was found be 0.9976, LOD, LOQ are 0.45 1.48 µg/ml. B first-order 269 0.9944, 0.29 0.96 C second-order 254 1.00, 0.62 2.04 D curve 266 300 0.9975, 0.14 0.46 All developed demonstrated good repeatability recovery with %RSD < 2. Studies on stress degradation show oxidation acid mostly impact solutions.
 Keywords: Carbamazepine, UV-spectrophotometric, Tegrital, Degradation study.